Liver Helpline India

Recent Posts


HOD & Senior Surgeon -
Liver Transplantation And Hepato-Pancraetic Biliary Surgery

View Profile


Which Patients Require Liver Transplant?

Which Patients Require Liver Transplant?

February 8, 2021


The liver is an important body organ and performs various metabolic functions. In the diseases that cause acute and chronic liver failure, the doctor may advise liver transplant. The patient undergoes a liver transplant when he is unable to get relief from medications and other surgeries.

Why Liver Transplant Is Required?

A liver transplant is a surgical intervention that involves replacing the diseased liver with a healthy liver. Patients require liver transplantation when there is a disease in the liver, and non-invasive and other invasive treatment methods did not provide relief from symptoms.

The donor of the liver may be living or dead. As the liver has the property of growing back into full size, the liver of a dead person can be transplanted into two people, i.e., one adult and one child. Liver transplant surgery is a complex surgery and the success of the surgery depends upon the quality of post-surgical care.

How To Reduce The Risk Of Liver Diseases?

The liver is an important organ and performs various important functions. It is important to take care of the liver. There are various ways to reduce the risk of liver diseases. Some of the ways are:

  • Limit the use of alcohol and quit smoking.
  • Prevent exposure to toxic chemicals
  • Manage your weight.
  • Eat a healthy diet.
  • Get treatment for the diseases that may increase the risk of liver diseases.

Which Patients Require Liver Transplant?

Patients suffering from an advanced, progressive and irreversible liver disease with severe liver dysfunction may require a liver transplant. Following are some disease requiring liver transplant:

Biliary atresia: The biliary system carries the bile from the liver to the small intestine. In biliary atresia, the biliary system is absent or not in a functional state. The bile accumulates in the liver causing damage to liver cells.

Liver cancer : Cancer may also make the liver dysfunctional. Cancer may be primary or secondary. The main types of liver cancer include hepatocellular carcinoma and hepatoblastoma.

Hepatitis: There are various causes of hepatitis. Virus, exposure to toxic substances, and bacteria may cause hepatitis. If left untreated, hepatitis may result in severe liver damage.

Primary Sclerosing Cholangitis: The bile ducts are important for carrying the bile to the intestine. In this condition, there is inflammation and scarring in the bile ducts. This results in the blockage of bile flow.

Alcoholic Liver Disease: The liver metabolizes alcohol. However, when a person consumed excessive alcohol for a prolonged period, it may result in liver damage. The disease, if left untreated, may progress to cause liver failure.

Non-alcoholic steatohepatitis: Non-alcoholic fatty liver disease involves the accumulation of fat in the liver. When this accumulation starts interfering in liver functioning, it leads to non-alcoholic steatohepatitis.

Autoimmune hepatitis: Autoimmune disease is a condition in which the immune cells perceive the body’s organs as threats and starts attacking them. In autoimmune hepatitis, the immune system attacks the liver cells and causes damage.

Metabolic Diseases: Various metabolic diseases may also require a liver transplant. These diseases include Alpha1-antitrypsin deficiency, Wilson’s disease, Glycogen storage disease, Urea cycle deficiency, Maple Syrup Urine Disease (MSUD), Tyrosinemia, and Neonatal hemochromatosis.

Revision surgery: Sometimes, the doctor advises the patient to undergo a liver transplant as revision surgery as the prior liver transplant surgery is unsuccessful.


Various diseases require liver transplantation. These are Non-alcoholic steatohepatitis, metabolic disease, alcoholic liver disease, primary biliary cholangitis, and metabolic diseases.